ABOUT OUR LAB
Stem cells have the ability to make more stem cells (self-renew) and also to give rise to differentiated cells. We are interested in the external and internal cues that regulate mammalian stem cell division and cell fate choice. We aim to study and compare these cues during homeostasis, tissue regeneration and tumorigenesis.
Main questions about tissue formation:
1) What intracellular and extracellular molecular cues control stem cell division and fate specification?
2) How do cells sort and self-organise to generate tissues?
3) How can we direct stem cell division to engineer organised human tissue models in vitro for regenerative medicine applications?
Immuno stainging of covalently immobilized Wnt3a proteins on magnetic beads
Yellow: Wnt3a bead White: Lrp6 3D reconstruction of Z stacks.
Red: beta catenin White: lrp6 receptor Yellow square: Wnt3a bead
Overly image: DIC Blue: DAPI Green: Sox2 (pluripotency marker) Black bead: Wnt3a-bead
© 2016 by Shukry Habib.