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Asymmetric Stem Cell Division and Tissue Formation 

ABOUT OUR LAB

​Stem cells have the ability to make more stem cells (self-renew) and also to give rise to differentiated cells. We are interested in the external and internal cues that regulate mammalian stem cell division and cell fate choice. We aim to study and compare these cues during homeostasis, tissue regeneration and tumorigenesis.
 

Main questions about stem cell division:

1) What intracellular and extracellular molecular cues control stem cell division?

 

2) How is cell fate choice determined?

    2a) Does oriented division dictate stem cell fate choice?

    2b) Does positioning of the daughter cells within the tissue determine their cell fate (stem cells vs. more differentiated cell)?

 

3) Can we harness the basic knowledge of stem cell division to engineer tissue models in vitro

Asymmetric Stem Cell Division

Overly image: DIC Blue: DAPI Green: Sox2 (pluripotency marker) Black bead: Wnt3a-bead