ABOUT OUR LAB
Stem cells have the ability to make more stem cells (self-renew) and also to give rise to differentiated cells. We are interested in the external and internal cues that regulate mammalian stem cell division and cell fate choice. We aim to study and compare these cues during homeostasis, tissue regeneration and tumorigenesis.
Main questions about tissue formation:
1) What intracellular and extracellular molecular cues control stem cell division and fate specification?
2) How do cells sort and self-organise to generate tissues?
3) Can we harness the basic knowledge of stem cell division to engineer tissue models in vitro?