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Asymmetric Stem Cell Division and Tissue Formation 

ABOUT OUR LAB

​Stem cells have the ability to make more stem cells (self-renew) and also to give rise to differentiated cells. We are interested in the external and internal cues that regulate mammalian stem cell division and cell fate choice. We aim to study and compare these cues during homeostasis, tissue regeneration and tumorigenesis.
 
Main questions about tissue formation:

1) What intracellular and extracellular molecular cues control stem cell division and fate specification?

 

2) How do cells sort and self-organise to generate tissues?

 

3) How can we direct stem cell division to engineer organised human tissue models in vitro for regenerative medicine applications? 

Wnt3a Beads
Wnt3a Beads

Immuno stainging of covalently immobilized Wnt3a proteins on magnetic beads

Single embryonic stem cell
Single embryonic stem cell

Yellow: Wnt3a bead White: Lrp6 3D reconstruction of Z stacks.

Wnt-mediated asymmetric division
Wnt-mediated asymmetric division

Red: beta catenin White: lrp6 receptor Yellow square: Wnt3a bead

Asymmetric Stem Cell Division
Asymmetric Stem Cell Division

Overly image: DIC Blue: DAPI Green: Sox2 (pluripotency marker) Black bead: Wnt3a-bead

© 2016 by Shukry Habib.

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